Kinetic Resolution of P-Chiral Phosphindole Oxides through Rhodium-Catalyzed Asymmetric Arylation
- Resource Type
- Article
- Authors
- Li, Wen-Cong; Ming, Jialin; Chen, Shufeng
- Source
- Organic Letters; May 2024, Vol. 26 Issue: 18 p3987-3990, 4p
- Subject
- Language
- ISSN
- 15237060; 15237052
Highly efficient kinetic resolution of P-chiral phosphindole oxides via rhodium-catalyzed asymmetric arylation under mild conditions is described. Selectivity factors of up to 569 were achieved by employing chiral diene*as a ligand. The transformation of the enantiopure benzophosphole derivative into a useful P-chiral bisphosphine ligand is also demonstrated.