Synthesis of 2-Aminophosphates via SN2-Type Ring Openings of Aziridines with Organophosphoric Acids
- Resource Type
- Article
- Authors
- Wang, Yang; Liu, Bing-Yi; Yang, Gaosheng; Chai, Zhuo
- Source
- Organic Letters; June 2019, Vol. 21 Issue: 12 p4475-4479, 5p
- Subject
- Language
- ISSN
- 15237060; 15237052
The synthesis of 2-aminophosphates is achieved by a SN2-type ring opening reaction of various N-protected or free aziridines with phosphoric acids in a regiospecific and/or enantiospecific way. A one-pot, two-step procedure is also developed enabling direct access to 2-aminophosphates from olefins without isolation of the aziridine intermediates.