Decreased Antibiotic Susceptibility Driven by Global Remodeling of the Klebsiella pneumoniaeProteome*[S]
- Resource Type
- Article
- Authors
- Keasey, Sarah L.; Suh, Moo-Jin; Das, Sudipto; Blancett, Candace D.; Zeng, Xiankun; Andresson, Thorkell; Sun, Mei G.; Ulrich, Robert G.
- Source
- Molecular and Cellular Proteomics (MCP Online); April 2019, Vol. 18 Issue: 4 p657-668, 12p
- Subject
- Language
- ISSN
- 15359476; 15359484
Keasey et al. investigate the proteomic mechanisms used to circumvent the effect of antibiotics by Gram-negative bacteria that do not harbor traditional genetic elements of resistance. The proteomes of Klebsiella pneumoniaebacteria that survived treatment with antibiotic inhibitors of ribosomal protein synthesis were examined by label-free quantitative mass spectrometry. Taking a systems approach, they identify both common and drug-specific molecular pathways that facilitate decreased susceptibility to antibiotics. These results explain why some antibiotic treatments fail even with sensitive pathogens.