The impact of guest molecule composition on the rotational dynamics in CH4, CO2, and mixed CH4–CO2gas hydrates is investigated with classical molecular dynamics simulations. Rotational autocorrelation functions are calculated for the guest and host molecules in each hydrate composition from simulation trajectories at 10, 40, 190, and 270 K. Analysis of these functions for each molecule is further decomposed into cage type for each CH4and CO2guest and cage face for the H2O host. CH4becomes more constrained, and CO2gains freedom in the mixed guest systems. Mixing guest species in gas hydrates alters the intermolecular interaction environment, impacting the rotational motion of the guest molecules. This effect is also seen in the host lattice H2O molecules, as evidence of molecular rotations is seen in the CO2hydrate at 270 K during longer simulations.