Palladium-Catalyzed Desymmetric Intermolecular C–N Coupling Enabled by a Chiral Monophosphine Ligand Derived from Anthracene Photodimer
- Resource Type
- Article
- Authors
- Wang, Xin; Liu, Wei-Gang; Liu, Lan-Tao; Yang, Xiao-Di; Niu, Shu; Tung, Chen-Ho; Wu, Li-Zhu; Cong, Huan
- Source
- Organic Letters; July 2021, Vol. 23 Issue: 14 p5485-5490, 6p
- Subject
- Language
- ISSN
- 15237060; 15237052
The development of chiral ligands with privileged scaffolds plays an important role in transition-metal-catalyzed asymmetric reactions. Herein we present anthracene-photodimer-derived chiral monophosphine ligand 1, which features dual chirality and a rigid scaffold. This ligand exhibits remarkable efficiency in Pd-catalyzed desymmetric intermolecular C–N coupling under mild conditions with excellent chemo- and enantioselectivity.