Iridium(III)-Catalyzed C–H Amidation/Cyclization of NH-Sulfoximines with N-Alkoxyamides: Formation of Thiadiazine 1-Oxides
- Resource Type
- Article
- Authors
- Xu, Hui-Bei; Yang, Jia-Hui; Chai, Xin-Yue; Zhu, Yan-Ying; Dong, Lin
- Source
- Organic Letters; March 2020, Vol. 22 Issue: 5 p2060-2063, 4p
- Subject
- Language
- ISSN
- 15237060; 15237052
The first example of Ir(III)-catalyzed C–H activation/cyclization with N-alkoxyamides as amidation reagents to simultaneously form functionalized thiadiazine 1-oxide derivatives was developed. This one-pot cascade protocol tolerated diverse functional groups and readily constructed various heterocyclic frameworks in moderate to good yield.