Retinoschisin is linked to retinal Na/K-ATPase signaling and localization
- Resource Type
- Article
- Authors
- Plössl, Karolina; Royer, Melanie; Bernklau, Sarah; Tavraz, Neslihan N.; Friedrich, Thomas; Wild, Jens; Weber, Bernhard H. F.; Friedrich, Ulrike
- Source
- Molecular Biology of the Cell; 2017, Vol. 28 Issue: 16 p2178-2189, 12p
- Subject
- Language
- ISSN
- 10591524; 19394586
Retinoschisin binds to the extracellular domain of Na/K-ATPase subunit β2. Retinoschisin inhibits Na/K-ATPase–associated signaling cascades and affects Na/K-ATPase localization. The retinoschisin-Na/K-ATPase complex overlaps with signaling mediators. Defective Na/K-ATPase signaling by retinoschisin deficiency may promote retinal dystrophy.