On-purpose propane dehydrogenation (PDH) has emerged as a profitable alternative to the traditional cracking of oil products for propylene production. By means of density functional theory (DFT) calculations, the present work demonstrates that Fe atoms may atomically disperse on MoS2(Fe1/MoS2) and serve as a promising single-atom catalyst (SAC) for PDH. The catalytic activity of Fe1/MoS2is attributed to the highly exposed d orbitals of single Fe atoms, while the propylene selectivity is originated from the kinetic inhibition of propylene dehydrogenation resulting from fast propenyl hydrogenation. The unique catalytic selectivity of Fe1/MoS2may inspire further investigations of on-purpose dehydrogenations of propane on SACs.