Separate cytotoxic T lymphocyte subsets recognize the different H-2 specificities.
- Resource Type
- Article
- Authors
- Vazquez, A; Néauport-Sautès, C; Senik, A
- Source
- The Journal of Experimental Medicine; March 1980, Vol. 151 Issue: 3 p773-780, 8p
- Subject
- Language
- ISSN
- 00221007; 15409538
Using a monolayer adsorption technique, the fine specificity of cytotoxic effector T lymphocytes (CTL) generated against allogeneic or semi-allogeneic H-2 haplotypes was investigated. The results show that: (a) CTL reacting with the private specificity expressed on an H-2.K molecule can be separated from those reacting with the public specificities expressed on the same molecule and (b) the CTL that recognize cross-reacting H-2 determinants (public specificities) can also be separated into several subpopulations. These data support the hypothesis that an allogeneic stimulation induces a large number of independent T cell clones that react with H-2 determinants.