Total ankle arthroplasty has been in development for more than 40 years. Although early designs were experimental with high failure rates, current implants are significantly improved, showing promising functional results and clinical outcomes. Total ankle replacement designs are split into mobile-bearing and fixed-bearing designs. When deciding whether to perform ankle arthroplasty, many factors need to be considered to determine if the patient is suitable and which implant is the best fit for patient and surgeon. Many prostheses are available in the United States today and the purpose of this article is to outline options for foot and ankle surgeons.