The deadly threat of systemic infections with coagulase negative Staphylococcus lugdunensisdespite an appropriate antibiotic therapy has only recently been recognized. The predominant infectious focus observed so far is left-sided native heart valve endocarditis, but bone and soft tissue infections, septicaemia and vascular catheter-related bloodstream infections have also been reported. We present a patient with a fatal Staphylococcus lugdunensissepticaemia following zoster bacterial superinfection of the pelvic region. A 71-year old male diagnosed with IgG kappa plasmocytoma presented with a conspicuous weight loss, a hypercalcaemic crisis and acute renal failure. After initiation of haemodialysis treatment his condition improved rapidly. However, he developed a varicella-zoster virus infection of the twelfth thoracic dermatome requiring intravenous acyclovir treatment. Four days later the patient presented with a fulminant septicaemia. Despite an early intravenous antibiotic therapy with ciprofloxacin, piperacillin/combactam and vancomycin the patient died within 48 hours, shortly before the infective isolate was identified as Staphylococcus lugdunensisby polymerase chain reaction. Despite S. lugdunensisbelonging to the family of coagulase-negative staphylococci with an usually low virulence, infections with S. lugdunensismay be associated with an aggressive course and high mortality. This is the first report on a Staphylococcus lugdunensissepticaemia following a zoster bacterial superinfection of the pelvic region.