Visible-Light-Promoted Radical Cross-Dehydrogenative Coupling of C(sp3)–H/C(sp3)–H and C(sp3)–H/C(sp2)–H via Intermolecular HAT
- Resource Type
- Article
- Authors
- Xie, Xinpeng; Qiao, Kaikai; Shao, Bing-ru; Jiang, Wenfeng; Shi, Lei
- Source
- Organic Letters; June 2023, Vol. 25 Issue: 23 p4264-4269, 6p
- Subject
- Language
- ISSN
- 15237060; 15237052
Cross-dehydrogenative coupling has emerged as a robust tool to construct C–C and C–heteroatom bonds. Herein, we reported an interesting visible-light-mediated radical CDC of C(sp3)–H/C(sp3)–H and C(sp3)–H/C(sp2)–H, enabled by a phenyl radical guided intermolecular HAT process. This strategy allowed the efficient coupling of a wide range of inert C(sp3)–H and C(sp2)–H with α-N C(sp3)–H of amines in good regioselectivities and yields. Mechanistic studies indicate that the EDA complex triggered an intermolecular HAT process.