In VitroMechanistic Study of the Distribution of Lascufloxacin into Epithelial Lining Fluid
- Resource Type
- Article
- Authors
- Ohya, Kouhei; Takano, Junichi; Manita, Shigeru
- Source
- Antimicrobial Agents and Chemotherapy; February 2019, Vol. 63 Issue: 4
- Subject
- Language
- ISSN
- 00664804; 10986596
The present study aimed to clarify the mechanism underlying the high distribution of lascufloxacin in epithelial lining fluid (ELF). Involvement of transporters was examined by transcellular transport across Calu-3 and transporter-overexpressing cells; the binding of lascufloxacin to ELF components was examined by an organic solvent-water partitioning system that employed pulmonary surfactant and phospholipids.