Semisyntheses, X-Ray Crystal Structures and Tubulin-Binding Properties of 7-Oxodeacetamidocolchicine and 7-Oxodeacetamidoisocolchicine
- Resource Type
- Article
- Authors
- Banwell, MG; Peters, SC; Greenwood, RJ; Mackay, MF; Hamel, E; Lin, CM
- Source
- Australian Journal of Chemistry; 1992, Vol. 45 Issue: 10 p1577-1588, 12p
- Subject
- Language
- ISSN
- 00049425; 14450038
Commercially available (–)-colchicine (1) has been converted, via deacetylcolchiceine (4), into a mixture of 7-oxodeacetamidocolchicine (2) and 7-oxodeacetamidoisocolchicine (3). The X-ray structures and tubulin-binding properties of these title ketones are described.