Background: AML is an aggressive and costly cancer to treat, which often results in lower quality of life, including worse and more frequent depression and anxiety, physical strains, and financial toxicity. AML can also have a considerable impact on social well-being, including personal and work domains. While individual social impacts of cancer are often considered, we propose that social toxicity is a unique construct-much like financial toxicity-that should be measured as such. This study aims to (1) determine the feasibility of creating a composite measure of social toxicity and (2) examine the prevalence of social toxicity in AML patients and survivors and its relationship to other patient reported outcomes.