Direct demonstration of an HLA-DR allotypic determinant on the low molecular weight (beta) subunit using a mouse monoclonal antibody specific for DR3
- Resource Type
- Article
- Authors
- Johnson, JP; Meo, T; Reithmuller, G; Schendel, DJ; Wank, R
- Source
- The Journal of Experimental Medicine; July 1982, Vol. 156 Issue: 1 p104-111, 8p
- Subject
- Language
- ISSN
- 00221007; 15409538
A murine monoclonal antibody directed against a human B cell surface antigen with the characteristics of HLA-DR is described. The antigen detected is tightly linked to HLA and is correlated with the alloantigen HLA-Dw/DR3. Reactivity with a fraction of Dw/DRw6 cells is also observed. The determinant recognized by this antibody has been shown to be present on the smaller molecular weight β subunit of the HLA-DR antigen.