Mild and efficient ammonium chloride catalyzed Greener synthesis of tetrahydro-β-carboline
- Resource Type
- Article
- Authors
- Gaikwad, Milind V.; Gaikwad, Sunil V.; Kamble, Rahul D.
- Source
- Current Research in Green and Sustainable Chemistry; January 2022, Vol. 5 Issue: 1
- Subject
- Language
- ISSN
- 26660865
This protocol involves the NH4Cl catalyzed Pictet−Spenglerreactions of tryptamine and arylaldehydes in anhydrous MeOH solvent to gives corresponding tetrahydro-β-carbolines (THβC) with 90% yield. This methodology offers mild, efficient and green reagent towards the synthesis THβC with tolerance of wide functional group. This is the first report of Pictet–Spenglerreaction using mild NH4Cl in MeOH solvent.