Supplemental Digital Content is Available in the Text.The vision-related quality of life in patients with non–center-involved diabetic macular edema was underrepresented. This community-based research indicates that these patients already exhibit changes in vision-related quality of life. Thus, proactive intervention against non–center-involved diabetic macular edema may not only enhance patient well-being but also curtail health-economic expenses, as evidenced by vision-related quality of life metrics.