Nouveaux traceurs en tomographie par émission de positons : un second souffle pour le ciblage de l’hypoxie tumorale ?
- Resource Type
- Article
- Authors
- Baillet, G.; Groheux, D.; Barré, E.; Toubert, M.-E.; Dechaud, C.; Teyton, P.; Le Beau de Hemricourt, E.; Moretti, J.-L.
- Source
- Médecine Nucléaire; December 2008, Vol. 32 Issue: 12 p607-613, 7p
- Subject
- Language
- ISSN
- 09281258
There is an increasing interest for targeting of tumor hypoxia and our paper aimed to emphasize the main points of this topic. We review new insights at cellular level and focus on the leading part of hypoxia inducible factor one alpha and its connections with angiogenesis. We shortly describe different methods to assess tissue hypoxia then zoom on to positron emission tomography and its acknowledged tracers 18F-fluoromisonidazole and 18F-fluoroerythronitroimidazole. Recent studies concerning two new promising tracers Cu(II)-diacetyl-bis(N(4)-methylthiosemicarbazone) and FAZA are reviewed, and the respective value of the tracers is discussed.