Vascular Endothelial Growth Factor (VEGF) Expression by Neoplastic Hodgkin-Reed-Sternberg Cells Is An Independent Adverse Prognostic Factor for Relapse in Hodgkin Lymphoma.
- Resource Type
- Article
- Authors
- Gutierrez, Antonio; Mestre, Francisco; Ramos, Rafael; Martinez-Serra, Jordi; Bautista, Antonia; Fuster, José; Lopez-Marti, Pilar; Casasus, Marta; Nicolau, Cristina; Rifa, Julio; Besalduch, Joan; Garcia, Juan Fernando; Rodriguez, Jose
- Source
- Blood; November 2009, Vol. 114 Issue: 22 p1561-1561, 1p
- Subject
- Language
- ISSN
- 00064971; 15280020
Middle and strong VEGF staining on neoplastic Hodgkin-Reed-Stenberg cells is associated with a greater risk for relapse and a worst PFS. However in this series this fact only affected OS in the strong staining cases. This could imply that these VEGF-positive cases may need a more intensive induction therapy and justify the development of trials including anti-VEGF or antiangiogenic drugs as part of therapeutic regimens in this malignancy.No relevant conflicts of interest to declare.