Based on the evidence identified in this rapid review, Hedera helixpreparations and herbal complex preparations including H. helixmay be a therapeutic option for treating early symptoms of respiratory tract infections. The best effectiveness for H. helixpreparations has been proven for coughing, as an expectorant and to reduce the frequency and intensity of cough. Only weak evidence was found for all other researched symptoms. Both adults and children tolerate H. helixwell. Currently, there is insufficient evidence to recommend the use of this supplement in the treatment or prevention of COVID-19. However, the current evidence justifies further research to better understand its applicability in coronavirus infections.