Purpose: To describe the use of 27-gauge pars plana vitrectomy in the management of Coats’ disease retinal detachment.Methods: Case report of a 10-year-old female presenting with exudative retinal detachment secondary to Coats’ disease. A two-port, 27-gauge pars plana vitrectomy, with one cannula in the subretinal space, was used to drain subretinal fluid. After resolution of the retinal detachment, a laser was directed to vascular abnormalities, and intravitreal antivascular endothelial growth factor was administered.Results: At 1 year follow-up, her retinal detachment remained resolved, peripheral vision had improved, and visual acuity had stabilized.Conclusions: A 27-gauge vitrectomy can be used successfully in the treatment of exudative Coats’ detachment. The use of valved trocars allows control of intraocular pressure and simultaneous controlled extrusion of subretinal fluid, decreasing the risk of retinal incarceration.