The article presents a case study of a 53-year-old Sinhalese woman with hyperlipidemia and von Willebrand’s disease who sought direct-to-consumer (DTC) whole exome sequencing (WES) and subsequent data analysis and interpretation. Her medical history, the challenges of interpreting exome data in patients with a medical history of a common, complex disease and of providing genetic counseling on rare genetic variants to such individuals, and single nucleotide polymorphisms (SNPs) are discussed.