An editorial is presented on the positive effects of polyphenol-rich foods on health and their potential to prevent chronic diseases. It highlights studies that explore the impact of polyphenols on various health aspects, such as brain health, obesity, diabetes, cardiometabolic health, and more. It also showcases the potential of polyphenol-rich foods, including cocoa, olive pomace oil, oat, and pistachios, in promoting overall well-being and preventing diseases.