Comparison of Organoid Swelling and Biomarkers of CFTR Function to Determine Effects of Lumacaftor-Ivacaftor in Patients with Cystic Fibrosis Homozygous for the F508del Mutation.
- Resource Type
- research
- Authors
- Graeber, Simon Y.; van Mourik, Peter; Vonk, Annelotte M.; Kruisselbrink, Evelien; Hirtz, Stephanie; van der Ent, Cornelis K.; Mall, Marcus A.; Beekman, Jeffrey M
- Source
- American Journal of Respiratory & Critical Care Medicine; 12/1/2020, Vol. 202 Issue 11, p1589-1592, 4p
- Subject
- ORGANOIDS
BIOMARKERS
CYSTIC fibrosis transmembrane conductance regulator
CYSTIC fibrosis treatment
GENETIC mutation measurement
- Language
- ISSN
- 1073449X
The article presents a research study and comparison of organoid swelling and In Vivo Biomarkers of cystic fibrosis transmembrane conductance regulator (CFTR) function. Topics include its aim to determine effects of drug, Lumacaftor–Ivacaftor in patients with cystic fibrosis homozygous for the F508del mutation.