An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth.
- Resource Type
- Article
- Authors
- Kundu, Parag; Genander, Maria; Strååt, Klas; Classon, Johanna; Ridgway, Rachel A.; Ee Hong Tan; Björk, Jan; Martling, Anna; van Es, Johan; Sansom, Owen J.; Clevers, Hans; Pettersson, Sven; Frisén, Jonas
- Source
- Science Translational Medicine; 4/1/2015, Vol. 7 Issue 281, p1-9, 9p, 5 Graphs
- Subject
- COCARCINOGENS
CARCINOMA
PROGENITOR cells
IMATINIB
DRUG therapy
CELL proliferation
ADENOMATOUS polyposis coli
- Language
- ISSN
- 19466234
The article looks at a study regarding tumor promoters for adenoma development but suppress progression to invasive carcinoma and EphB receptors regulate the proliferation and positioning of intestinal stem and progenitor cells. It mentions imatinib treatment extended the life span mice and reduced cell proliferation in cultured slices of adenomas from patients with familial adenomatous polyposis. It also mentions clinical implications for pharmacological therapy.