Management of Recessive Dystrophic Epidermolysis Bullosa in a Newborn with Porcine-derived Extracellular Matrix.
- Resource Type
- Report
- Authors
- Le NK; University of South Florida Morsani College of Medicine, Tampa, Fla.; Billington A; Department of Plastic Surgery, University of South Florida Morsani College of Medicine, Tampa, Fla.; Harrington M; Department of Plastic Surgery, University of South Florida Morsani College of Medicine, Tampa, Fla.; Seminario-Vidal L; Department of Dermatology and Cutaneous Surgery, University of South Florida Morsani College of Medicine, Tampa, Fla.
- Source
- Publisher: Wolters Kluwer Health/Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101622231 Publication Model: eCollection Cited Medium: Print ISSN: 2169-7574 (Print) Linking ISSN: 21697574 NLM ISO Abbreviation: Plast Reconstr Surg Glob Open Subsets: PubMed not MEDLINE
- Subject
- Language
- English
- ISSN
- 2169-7574
Epidermolysis bullosa is a debilitating dermatologic disorder affecting the adhesive capability between the epidermis and dermis. The severe recessive dystrophic variant is caused by mutations in COL7A1, the gene encoding type VII collagen which is the major structural protein of the anchoring fibrils linking these 2 skin layers.1 The management of recessive dystrophic epidermolysis bullosa (RDEB) remains complex with no curative therapy. We present herein the novel use of a porcinederived extracellular matrix dressing to effectively treat extensive erosions in a newborn.
(Copyright © 2019 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.)