Electronic considerations in the mutagenesis of some 4,5-bridged chrysenes.
- Resource Type
- Academic Journal
- Authors
- Lee-Ruff E; Raj AS; Kruk H; Katz M
- Source
- Publisher: Liss Country of Publication: United States NLM ID: 7909737 Publication Model: Print Cited Medium: Print ISSN: 0192-2521 (Print) Linking ISSN: 01922521 NLM ISO Abbreviation: Environ Mutagen Subsets: MEDLINE
- Subject
- Language
- English
- ISSN
- 0192-2521
The mutagenic activity of four 4,5-bridged chrysene derivatives, benz(a)aceanthrylene, and 5-methylchrysene was examined using histidine auxotrophic strains TA98 and TA100 of Salmonella typhimurium. All compounds showed a positive mutagenic response with both TA100 and TA98 in the presence of S-9. A correlation between the electronic character of the bridging group and mutagenic activity for the chrysene derivatives is proposed.