Grafting of Bioactive Polymers with Various Architectures: A Versatile Tool for Preparing Antibacterial Infection and Biocompatible Surfaces.
- Resource Type
- Academic Journal
- Authors
- Chouirfa H; LBPS/CSPBAT, UMR CNRS 7244, Institut Galilée, Université Paris 13, Sorbonne Paris Cité , 99 avenue JB Clément, 93340 Villetaneuse, France.; Evans MDM; CSIRO Biomedical Materials Manufacturing Program , 11 Julius Avenue, North Ryde, Sydney, NSW 2113, Australia.; Bean P; CSIRO Biomedical Materials Manufacturing Program , 11 Julius Avenue, North Ryde, Sydney, NSW 2113, Australia.; Saleh-Mghir A; Département de Médecine Aigüe Spécialisée, Hôpital Universitaire Raymond-Poincaré, Assistance Publique-Hôpitaux de Paris, Garches, and UMR 1173, Faculté de Médecine Paris-Île-de-France Ouest, Université Versailles-Saint-Quentin , 78000 Versailles, France.; Crémieux AC; Département de Médecine Aigüe Spécialisée, Hôpital Universitaire Raymond-Poincaré, Assistance Publique-Hôpitaux de Paris, Garches, and UMR 1173, Faculté de Médecine Paris-Île-de-France Ouest, Université Versailles-Saint-Quentin , 78000 Versailles, France.; Castner DG; National ESCA and Surface Analysis Center for Biomedical Problems, Departments of Bioengineering and Chemical Engineering, University of Washington , Seattle, Washington 98195-1653, United States.; Falentin-Daudré C; LBPS/CSPBAT, UMR CNRS 7244, Institut Galilée, Université Paris 13, Sorbonne Paris Cité , 99 avenue JB Clément, 93340 Villetaneuse, France.; Migonney V; LBPS/CSPBAT, UMR CNRS 7244, Institut Galilée, Université Paris 13, Sorbonne Paris Cité , 99 avenue JB Clément, 93340 Villetaneuse, France.
- Source
- Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE
- Subject
- Language
- English
The aim of this Research Article is to present three different techniques of poly(sodium styrene sulfonate) (polyNaSS) covalent grafting onto titanium (Ti) surfaces and study the influence of their architecture on biological response. Two of them are "grafting from" techniques requiring an activation step either by thermal or UV irradiation. The third method is a "grafting to" technique involving an anchorage molecule onto which polyNaSS synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization is clicked. The advantage of the "grafting to" technique when compared to the "grafting from" technique is the ability to control the architecture and length of the grafted polymers on the Ti surface and their influence on the biological responses. This investigation compares the effect of the three different grafting processes on the in vitro biological responses of bacteria and osteoblasts. Overall outcomes of this investigation confirmed the significance of the sulfonate functional groups on the biological responses, regardless of the grafting method. In addition, results showed that the architecture and distribution of grafted polyNaSS on Ti surfaces alter the intensity of the bacteria response mediated by fibronectin.