The renal transport of hippurate and protein-bound solutes.
- Resource Type
- Academic Journal
- Authors
- Kumar R; NYU School of Medicine, New York, NY, USA.; Adiga A; NYU School of Medicine, New York, NY, USA.; Novack J; NYU School of Medicine, New York, NY, USA.; Etinger A; NYU School of Medicine, New York, NY, USA.; Chinitz L; NYU School of Medicine, New York, NY, USA.; Slater J; NYU School of Medicine, New York, NY, USA.; de Loor H; Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.; Meijers B; Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium.; Holzman RS; NYU School of Medicine, New York, NY, USA.; Lowenstein J; NYU School of Medicine, New York, NY, USA.
- Source
- Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE
- Subject
- Language
- English
Measurement of the concentration of hippurate in the inferior vena cava and renal blood samples performed in 13 subjects with normal or near-normal serum creatinine concentrations confirmed the prediction that endogenous hippurate was cleared on a single pass through the kidney with the same avidity as that reported for infused para-amino hippurate. This suggests that a timed urine collection without infusion would provide a measure of effective renal plasma flow. Comparison of the arteriovenous concentration differences for a panel of protein-bound solutes identified solutes that were secreted by the renal tubule and solutes that were subjected to tubular reabsorption.
(© 2020 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.)