GD2 target antigen and CAR T cells: does it take more than 2 to tango?
- Resource Type
- Academic Journal
- Authors
- Locatelli F; Bambino Gesù Children's Hospital, Rome, Italy.; Quintarelli C; IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy.
- Source
- Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
- Subject
- Language
- English
Over the past decade, chimeric antigen receptor (CAR) T cells have emerged as a breakthrough cancer therapy in selected hematological malignancies. Translating the success of this therapy to solid tumors is challenging. Here, we discuss strategies potentially useful to increase the CAR T-cell efficacy in this clinical indication.