Medical fluorophore 1 (MF1), a benzoquinolizinium-based fluorescent dye, as an inflammation imaging agent.
- Resource Type
- Academic Journal
- Authors
- Lee SB; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Chembok-ro Dong-gu Daegu, Republic of Korea. dongsukim1127@dgmif.re.kr sjcho@dgmif.re.kr.; Han YR; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Chembok-ro Dong-gu Daegu, Republic of Korea. dongsukim1127@dgmif.re.kr sjcho@dgmif.re.kr.; Jeon HJ; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Chembok-ro Dong-gu Daegu, Republic of Korea. dongsukim1127@dgmif.re.kr sjcho@dgmif.re.kr.; Jun CH; Department of Chemistry, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea and Center for NanoMedicine, Institute for Basic Science (IBS), Seoul, Republic of Korea and Yonsei-IBS Institute, Yonsei University, Seoul 03722, Republic of Korea.; Kim SK; Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Chembok-ro Dong-gu Daegu, Republic of Korea. jeon9014@gmail.com.; Chin J; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Chembok-ro Dong-gu Daegu, Republic of Korea. dongsukim1127@dgmif.re.kr sjcho@dgmif.re.kr.; Lee SJ; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Chembok-ro Dong-gu Daegu, Republic of Korea. dongsukim1127@dgmif.re.kr sjcho@dgmif.re.kr.; Jeong M; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Chembok-ro Dong-gu Daegu, Republic of Korea. dongsukim1127@dgmif.re.kr sjcho@dgmif.re.kr.; Lee JE; Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Chembok-ro Dong-gu Daegu, Republic of Korea. jeon9014@gmail.com and Department of Biomaterials Science, College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Pusan, Republic of Korea.; Lee CH; Department of Chemistry, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea and Center for NanoMedicine, Institute for Basic Science (IBS), Seoul, Republic of Korea and Yonsei-IBS Institute, Yonsei University, Seoul 03722, Republic of Korea.; Cho SJ; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Chembok-ro Dong-gu Daegu, Republic of Korea. dongsukim1127@dgmif.re.kr sjcho@dgmif.re.kr.; Kim DS; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Chembok-ro Dong-gu Daegu, Republic of Korea. dongsukim1127@dgmif.re.kr sjcho@dgmif.re.kr.; Jeon YH; Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Chembok-ro Dong-gu Daegu, Republic of Korea. jeon9014@gmail.com.
- Source
- Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101598493 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2050-7518 (Electronic) Linking ISSN: 2050750X NLM ISO Abbreviation: J Mater Chem B Subsets: MEDLINE
- Subject
- Language
- English
Structure-based targeting of fluorescent dyes is essential for their use as imaging agents for disease diagnosis. Here, we describe the development of the benzoquinolizinium compound Medical fluorophore 1 (MF1) as a novel biomedical imaging agent that allows the visualization of inflammation by virtue of its unique chemical structure. Lipopolysaccharide treatment stimulated the uptake of MF1 by bone marrow-derived macrophages, with no adverse effects on cell proliferation. In vivo fluorescence lifetime imaging revealed the accumulation of MF1 in carrageenan-induced acute inflammatory lesions in mice, which peaked at 6 h. MF1-based imaging also allowed monitoring of the response to the anti-inflammatory drugs dexamethasone and sulfasalazine. Thus, MF1 can be used to diagnose diseases characterized by inflammation as well as treatment efficacy.