Endoscopic third ventriculostomy for adults with hydrocephalus: creating a prognostic model for success: protocol for a retrospective multicentre study (Nordic ETV).
- Resource Type
- Academic Journal
- Authors
- Tefre S; Department of Neurosurgery, Rigshospitalet, Copenhagen, Denmark sondre.tefre@regionh.dk.; Lilja-Cyron A; Department of Neurosurgery, Rigshospitalet, Copenhagen, Denmark.; Arvidsson L; Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.; Bartek J; Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.; Corell A; Department of Neurosurgery, Sahlgrenska University Hospital, Goteborg, Sweden.; Forsse A; Department of Neurosurgery, Odense University Hospital, Odense, Denmark.; Glud AN; Department of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark.; Hamdeh SA; Department of Neurosurgery, Uppsala University Hospital, Uppsala, Sweden.; Hansen FL; Department of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark.; Huotarinen A; Department of Neurosurgery NeuroCenter, Kuopio University Hospital, Kuopio, Pohjois-Savo, Finland.; Johansson C; Department of Neurosurgery, University Hospital of Umeå, Umeå, Sweden.; Kämäräinen OP; Department of Neurosurgery NeuroCenter, Kuopio University Hospital, Kuopio, Pohjois-Savo, Finland.; Korhonen T; Department of Neurosurgery, Oulu University Hospital, Oulu, Finland.; Research Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland.; Kotkansalo A; Department of Neurosurgery and Brain Injury Centre, Turku University Hospital, Turku, Finland.; Mansoor NM; Department of Neurosurgery, St Olavs Hospital Universitetssykehuset i Trondheim, Trondheim, Trøndelag, Norway.; Mendoza Mireles EE; Department of Neurosurgery, Oslo University Hospital Ullevaal, Oslo, Norway.; Department of Neurosurgery, Rikshospitalet University Hospital, Oslo, Norway.; Miscov R; Department of Neurosurgery, Aalborg University Hospital, Aalborg, North Denmark Region, Denmark.; Munthe S; Department of Neurosurgery, Odense University Hospital, Odense, Denmark.; Nittby-Redebrandt H; Department of Neurosurgery, Lund University Hospital, Lund, Sweden.; Obad N; Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway.; Pedersen LK; Department of Neurosurgery, University Hospital of North Norway, Tromso, Norway.; Posti J; Department of Neurosurgery and Brain Injury Centre, Turku University Hospital, Turku, Finland.; Raj R; Department of Neurosurgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.; Satopää J; Department of Neurosurgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.; Ståhl N; Department of Neurosurgery, Lund University Hospital, Lund, Sweden.; Tetri S; Department of Neurosurgery, Oulu University Hospital, Oulu, Finland.; Research Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland.; Tobieson L; Department of Neurosurgery in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, Linkoping, Östergötland, Sweden.; Juhler M; Department of Neurosurgery, Rigshospitalet, Copenhagen, Denmark.
- Source
- Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
- Subject
- Language
- English
Introduction: Endoscopic third ventriculostomy (ETV) is becoming an increasingly widespread treatment for hydrocephalus, but research is primarily based on paediatric populations. In 2009, Kulkarni et al created the ETV Success score to predict the outcome of ETV in children. The purpose of this study is to create a prognostic model to predict the success of ETV for adult patients with hydrocephalus. The ability to predict who will benefit from an ETV will allow better primary patient selection both for ETV and shunting. This would reduce additional second procedures due to primary treatment failure. A success score specific for adults could also be used as a communication tool to provide better information and guidance to patients.
Methods and Analysis: The study will adhere to the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis reporting guidelines and conducted as a retrospective chart review of all patients≥18 years of age treated with ETV at the participating centres between 1 January 2010 and 31 December 2018. Data collection is conducted locally in a standardised database. Univariate analysis will be used to identify several strong predictors to be included in a multivariate logistic regression model. The model will be validated using K-fold cross validation. Discrimination will be assessed using area under the receiver operating characteristic curve (AUROC) and calibration with calibration belt plots.
Ethics and Dissemination: The study is approved by appropriate ethics or patient safety boards in all participating countries.
Trial Registration Number: NCT04773938; Pre-results.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)