Clinical Utility of Flow Cytometry for Detection of Anti-Jk b IgM in Acute Haemolytic Transfusion Reaction.
- Resource Type
- Academic Journal
- Authors
- Nagaharu K; Department of Hematology, Mie University Hospital, Japan.; Department of Hematology, Yokkaichi Municipal Hospital, Japan.; Department of Hematology, Japanese Red Cross Ise Hospital, Japan.; Izumi T; Department of Hematology, Japanese Red Cross Ise Hospital, Japan.; Maruyama M; Transfusion Medicine and Cell Therapy, Mie University Hospital, Japan.; Sugimoto Y; Department of Hematology, Mie University Hospital, Japan.; Ohishi K; Transfusion Medicine and Cell Therapy, Mie University Hospital, Japan.; Tawara I; Department of Hematology, Mie University Hospital, Japan.; Usui E; Department of Hematology, Japanese Red Cross Ise Hospital, Japan.; Tamaki S; Department of Hematology, Japanese Red Cross Ise Hospital, Japan.
- Source
- Publisher: Japanese Society of Internal Medicine Country of Publication: Japan NLM ID: 9204241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7235 (Electronic) Linking ISSN: 09182918 NLM ISO Abbreviation: Intern Med Subsets: MEDLINE
- Subject
- Language
- English
Acute hemolytic transfusion reaction (AHTR) is a rare but life-threatening complication of transfusion. We herein report a case of anti-Jk b IgM-related AHTR. Two hours after an 80-year-old man with myelodysplastic syndrome received a packed red blood cell (RBC) A + /Rh - /Jk b+/ c - transfusion, he developed acute respiratory failure and a fever. Although he had tested negative in routine screening tests, the 37°C normal saline test was weakly positive for Jk b . We confirmed the presence of anti-Jk b IgM in the patient's serum by flow cytometry. This case demonstrates the potential utility of flow cytometry for IgM detection.