Association of severity and mortality of Covid-19 cases among acute kidney injury and sexual dimorphism.
- Resource Type
- Academic Journal
- Authors
- Singh MK; Department of Urology, King George's Medical University, Chowk, Lucknow, Uttar Pradesh, 226003, India.; Jain M; Department of Thoracic Surgery, King George's Medical University, Lucknow, UP, 226003, India.; Shyam H; Department of Thoracic Surgery, King George's Medical University, Lucknow, UP, 226003, India.; Sahu DK; Super Speciality Paediatric Hospital & Post Graduate Teaching Institute, Noida, UP, 201301, India.; Mishra A; Department of Thoracic Surgery, King George's Medical University, Lucknow, UP, 226003, India.; Shankar P; Department of Centre for Advance Research, King George's Medical University, Lucknow, UP, 226003, India.; Kumar S; Department of Thoracic Surgery, King George's Medical University, Lucknow, UP, 226003, India.; Singh V; Department of Urology, King George's Medical University, Chowk, Lucknow, Uttar Pradesh, 226003, India. drvishwajeet68@gmail.com.
- Source
- Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE
- Subject
- Language
- English
Introduction: The outbreak of coronavirus disease 2019 (Covid-19) severely impacted global health and economic status. The native receptor-ligand interaction of Angiotensin-converting enzyme 2 (ACE2) and S protein induces host cell pathogenesis via immunosuppression.
Material and Methods: The emerging evidence reports the sex disparity in Covid-19 induced mortality rate which affects abundantly men population. Although the biological interaction of Covid-19 with receptor upregulates the viral genome protein interactions and initiates the predictive multiorgan failure followed by acute kidney injury (AKI) in Covid-19 infected male population.
Conclusion: Besides, the knowledge and lessons learned from the study depict that cellular and molecular links may explain the risk and severity of Covid-19 and AKI in the male population and lead to management of Covid-19 induced AKI. Therefore, this review explored the pathways associated with the pathogenesis of two diseased conditions with sex disparity.
(© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)