Air pollution during the perinatal period and neurodevelopment in children: A national population study in Taiwan.
- Resource Type
- Academic Journal
- Authors
- Shih P; Department of Environmental and Occupational Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Environmental and Occupational Medicine, National Taiwan University, Taipei, Taiwan.; Department of Environmental and Occupational Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.; Chiang TL; Institute of Health Policy and Management, College of Public Health, National Taiwan University, Taipei, Taiwan.; Wu CD; Department of Geomatics, National Cheng Kung University, Tainan, Taiwan.; National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.; Shu BC; Institute of Allied Health Sciences, Department of Nursing, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Lung FW; Calo Psychiatric Center, Pingtung, Taiwan.; Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan.; Guo YL; Department of Environmental and Occupational Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Environmental and Occupational Medicine, National Taiwan University, Taipei, Taiwan.; National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.; Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Taipei, Taiwan.
- Source
- Publisher: Blackwell Country of Publication: England NLM ID: 0006761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8749 (Electronic) Linking ISSN: 00121622 NLM ISO Abbreviation: Dev Med Child Neurol Subsets: MEDLINE
- Subject
- Language
- English
Aim: To evaluate the association between ambient particulate matter no larger than 2.5 μm in diameter (PM 2.5 ) during the prenatal and postnatal periods and infant neurodevelopmental parameters.
Method: We conducted a population-based birth cohort study using the Taiwan Birth Cohort Study. Participants were assessed for developmental conditions through home interviews at 6 months and 18 months of age. Exposure to PM 2.5 of mothers and infants during perinatal periods was estimated using hybrid kriging/land-use regression. The exposure was linked to each participant by home address. Logistic regression was then conducted to determine the risk of neurodevelopmental delay in relation to PM 2.5 .
Results: A total of 17 683 term singletons without congenital malformations were included in the final analysis. PM 2.5 during the second trimester was associated with increased risks of delays in gross motor neurodevelopmental milestones (adjusted odds ratio [aOR] 1.09 per 10 μg/m 3 increase in exposure to PM 2.5 ). Delayed fine motor development was also found to be related to exposure to PM 2.5 in the second and third trimesters (aOR 1.06), as was personal-social skill (aOR 1.11 for the second trimester and 1.06 for the third). These neurodevelopmental parameters were unrelated to postnatal PM 2.5 exposure.
Interpretation: Exposure to ambient PM 2.5 during pregnancy was significantly related to delay in gross motor, fine motor, and personal-social development in this population-based study.
What This Paper Adds: Prenatal exposure to higher PM 2.5 was associated with increased risk of delayed early neurodevelopment. The critical period for delayed gross motor development was the second trimester. The critical period for fine motor and personal-social development was the second and third trimesters.
(© 2022 Mac Keith Press.)