Competing Interests: Conflicts of interest: J.J. Zulueta reports medical advisor roles for HeartLung Technologies, Median Technologies, Disit Biotech and OncoSwab. L.M. Seijo reports consulting for Median Technologies, Serum Detect, Sabartech, Roche and AstraZeneca, has received professional fees for speaking engagements from Roche, AstraZeneca and Menarini, and collaborated in scientific meetings or received institutional research grants from Serum Detect, Lung Ambition Alliance, Menarini and Esteve Pharmaceuticals.