Calculating Utilities From the Spine Oncology Study Group Outcomes Questionnaire: A Necessity for Economic and Decision Analysis.
- Resource Type
- Academic Journal
- Authors
- Pahuta MA; Division of Orthopedic Surgery, McMaster University, Hamilton, ON, Canada.; Fisk F; Department of Orthopedics, Henry Ford Health System, Detroit, MI.; Versteeg AL; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands and Department of Orthopaedic Surgery, University of Toronto, Toronto, Ontario, Canada.; Fisher CG; Division of Spine, Surgery Vancouver Spine Surgery Institute, Vancouver General Hospital University of British Columbia, Vancouver, Canada.; Sahgal A; Department of Radiation Oncology, Sunnybrook Odette Cancer Center and University of Toronto, Toronto, Ontario, Canada.; Gokaslan ZL; Department of Neurosurgery, The Warren Alpert Medical School of Brown University and Rhode Island Hospital and The Miriam Hospital, Providence, RI.; Reynolds JJ; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Laufer I; Department of Neurosurgery, NYU Grossman School of Medicine, New York, NY.; Lazary A; National Center for Spinal Disorders and Buda Health Center, Budapest, Hungary.; Rhines LD; Department of Neurosurgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX.; Boriani S; Spine Surgery Division, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.; Bettegowda C; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD.; Dea N; Division of Spine, Surgery Vancouver Spine Surgery Institute, Vancouver General Hospital University of British Columbia, Vancouver, Canada.
- Source
- Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7610646 Publication Model: Print Cited Medium: Internet ISSN: 1528-1159 (Electronic) Linking ISSN: 03622436 NLM ISO Abbreviation: Spine (Phila Pa 1976) Subsets: MEDLINE
- Subject
- Language
- English
Study Design: General population utility valuation study.
Objective: The aim of this study was to develop a technique for calculating utilities from the Spine Oncology Study Group Outcomes Questionnaire v2.0 (SOSGOQ2.0).
Summary of Background Data: The ability to calculate quality-adjusted life-years (QALYs) for metastatic spine disease would enhance treatment decision-making and facilitate economic analysis. QALYs are calculated using utilities.
Methods: Using a hybrid concept-retention and factorial analysis shortening approach, we first shortened the SOSGOQ2.0 to eight items (SOSGOQ-8D). This was done to lessen the cognitive burden of the utility valuation exercise. A general population sample of 2730 adults was then asked to evaluate 12 choice sets based on SOSGOQ-8D health states in a Discrete Choice Experiment. A utility scoring rubric was then developed using a mixed multinomial-logit regression model.
Results: We were able to reduce the SOSGOQ2.0 to an SOSGOQ-8D with a mean error of 0.003 and mean absolute error of 3.078 compared to the full questionnaire. The regression model demonstrated good predictive performance and was used to develop a utility scoring rubric. Regression results revealed that participants did not regard all SOSGOQ-8D items as equally important.
Conclusion: We provide a simple technique for converting the SOSGOQ2.0 to utilities. The ability to evaluate QALYs in metastatic spine disease will facilitate economic analysis and patient counseling. We also quantify the importance of individual SOSGOQ-8D items. Clinicians should heed these findings and offer treatments that maximize function in the most important items.Level of Evidence: 3.
(Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.)