GENOME REPORT: Chromosome-scale genome assembly of the African spiny mouse ( Acomys cahirinus ).
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- Nguyen ED; Department of Pediatrics, University of Washington, Seattle, WA.; Center for Developmental Biology & Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA.; Brotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA.; Fard VN; School of Informatics, Computing, and Cyber Systems, Northern Arizona University, Flagstaff, AZ.; Kim BY; Department of Biology, Stanford University, Stanford, CA.; Collins S; Center for Developmental Biology & Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA.; Galey M; Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, WA.; Nelson BR; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA.; Wakenight P; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA.; Gable SM; School of Informatics, Computing, and Cyber Systems, Northern Arizona University, Flagstaff, AZ.; McKenna A; Department of Molecular & Systems Biology, Dartmouth Geisel School of Medicine, Lebanon, NH.; Bammler TK; Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA.; MacDonald J; Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA.; Okamura DM; Department of Pediatrics, University of Washington, Seattle, WA.; Center for Developmental Biology & Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA.; Shendure J; Brotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA.; Department of Genome Sciences, University of Washington, Seattle, WA.; Allen Discovery Center for Cell Lineage Tracing, Seattle, WA.; Howard Hughes Medical Institute, Seattle, WA.; Institute of Stem Cell & Regenerative Medicine, University of Washington, Seattle, WA.; Beier DR; Department of Pediatrics, University of Washington, Seattle, WA.; Center for Developmental Biology & Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA.; Ramirez JM; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA.; Department of Neurological Surgery, University of Washington, Seattle WA.; Majesky MW; Department of Pediatrics, University of Washington, Seattle, WA.; Center for Developmental Biology & Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA.; Institute of Stem Cell & Regenerative Medicine, University of Washington, Seattle, WA.; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA.; Millen KJ; Department of Pediatrics, University of Washington, Seattle, WA.; Brotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA.; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA.; Tollis M; School of Informatics, Computing, and Cyber Systems, Northern Arizona University, Flagstaff, AZ.; Miller DE; Brotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA.; Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, WA.; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA.
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- Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
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- English
There is increasing interest in the African spiny mouse ( Acomys cahirinus ) as a model organism because of its ability for regeneration of tissue after injury in skin, muscle, and internal organs such as the kidneys. A high-quality reference genome is needed to better understand these regenerative properties at the molecular level. Here, we present an improved reference genome for A. cahirinus generated from long Nanopore sequencing reads. We confirm the quality of our annotations using RNA sequencing data from four different tissues. Our genome is of higher contiguity and quality than previously reported genomes from this species and will facilitate ongoing efforts to better understand the regenerative properties of this organism.