Detection of STRN-ALK fusion in thyroid nodules with indeterminate cytopathology facilitates papillary thyroid cancer diagnosis.
- Resource Type
- Academic Journal
- Authors
- Jurkiewicz M; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Cimic A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Murty VV; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Kuo JH; Department of Surgery, Columbia University Irving Medical Center, New York, New York, USA.; Hsiao S; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Fazlollahi L; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Fernandes H; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.
- Source
- Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8506895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0339 (Electronic) Linking ISSN: 10970339 NLM ISO Abbreviation: Diagn Cytopathol Subsets: MEDLINE
- Subject
- Language
- English
Thyroid cancer is the most common endocrine malignancy. Approximately 70% of cases of papillary thyroid carcinoma and 50% of poorly differentiated and anaplastic thyroid carcinoma harbor well-characterized driver mutations and chromosomal rearrangements that drive tumorigenesis. Molecular profiling has been helpful in identifying and informing follow-up strategies in tumors with more aggressive trajectories. Here, we report a case of papillary thyroid cancer (PTC) discovered in a patient with thyroid nodules with relatively benign ultrasound and fine needle aspiration (FNA) findings. Molecular testing in this patient identified a rare STRN-ALK fusion in two thyroid nodules with indeterminate and/or benign cytology. This led to the patient undergoing a thyroid lobectomy and a subsequent confirmation of papillary thyroid carcinoma upon resection. The report highlights the role of comprehensive molecular testing in thyroid lesions of indeterminate cytology.
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