Eco-friendly and effective antimicrobial Melaleuca alternifolia essential oil Pickering emulsions stabilized with cellulose nanofibrils against bacteria and SARS-CoV-2.
- Resource Type
- Academic Journal
- Authors
- da S Ferreira G; Center for Engineering, Modeling, and Applied Social Sciences (CECS), Federal University of ABC (UFABC), Av. dos Estados, 5001, CEP 09210-210 Santo André, SP, Brazil.; da Silva DJ; Center for Engineering, Modeling, and Applied Social Sciences (CECS), Federal University of ABC (UFABC), Av. dos Estados, 5001, CEP 09210-210 Santo André, SP, Brazil.; Souza AG; Center for Engineering, Modeling, and Applied Social Sciences (CECS), Federal University of ABC (UFABC), Av. dos Estados, 5001, CEP 09210-210 Santo André, SP, Brazil.; Yudice EDC; Adolfo Lutz Institute, Santo André Regional Center, Av. Ramiro Colleoni, 240, CEP 09040-160 Santo André, SP, Brazil.; de Campos IB; Adolfo Lutz Institute, Santo André Regional Center, Av. Ramiro Colleoni, 240, CEP 09040-160 Santo André, SP, Brazil.; Col RD; Adolfo Lutz Institute, Santo André Regional Center, Av. Ramiro Colleoni, 240, CEP 09040-160 Santo André, SP, Brazil.; Mourão A; Center for Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Av. dos Estados, 5001, CEP 09210-210 Santo André, SP, Brazil.; Martinho HS; Center for Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Av. dos Estados, 5001, CEP 09210-210 Santo André, SP, Brazil.; Rosa DS; Center for Engineering, Modeling, and Applied Social Sciences (CECS), Federal University of ABC (UFABC), Av. dos Estados, 5001, CEP 09210-210 Santo André, SP, Brazil. Electronic address: dervalrosa@yahoo.com.br.
- Source
- Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
- Subject
- Language
- English
Melaleuca alternifolia essential oil (MaEO) is a green antimicrobial agent suitable for confection eco-friendly disinfectants to substitute conventional chemical disinfectants commonly formulated with toxic substances that cause dangerous environmental impacts. In this contribution, MaEO-in-water Pickering emulsions were successfully stabilized with cellulose nanofibrils (CNFs) by a simple mixing procedure. MaEO and the emulsions presented antimicrobial activities against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Moreover, MaEO deactivated the SARS-CoV-2 virions immediately. FT-Raman and FTIR spectroscopies indicate that the CNF stabilizes the MaEO droplets in water by the dipole-induced-dipole interactions and hydrogen bonds. The factorial design of experiments (DoE) indicates that CNF content and mixing time have significant effects on preventing the MaEO droplets' coalescence during 30-day shelf life. The bacteria inhibition zone assays show that the most stable emulsions showed antimicrobial activity comparable to commercial disinfectant agents such as hypochlorite. The MaEO/water stabilized-CNF emulsion is a promissory natural disinfectant with antibacterial activity against these bacteria strains, including the capability to damage the spike proteins at the SARS-CoV-2 particle surface after 15 min of direct contact when the MaEO concentration is 30 % v/v.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)