Tau Aggregation Correlates with Amyloid Deposition in Both Mild Cognitive Impairment and Alzheimer's Disease Subjects.
- Resource Type
- Academic Journal
- Authors
- Dani M; Neurology Imaging Unit, Department of Medicine, Imperial College London, London, UK.; Wood M; Neurology Imaging Unit, Department of Medicine, Imperial College London, London, UK.; Mizoguchi R; Neurology Imaging Unit, Department of Medicine, Imperial College London, London, UK.; Fan Z; Neurology Imaging Unit, Department of Medicine, Imperial College London, London, UK.; Edginton T; Department of Psychology, City University of London, London, UK.; Hinz R; Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.; Win Z; Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK.; Brooks DJ; Neurology Imaging Unit, Department of Medicine, Imperial College London, London, UK.; Department of Nuclear Medicine, Aarhus University, Aarhus, Denmark.; Institute of Neuroscience, University of Newcastle upon Tyne, Newcastle University Campus for Ageing and Vitality, Newcastle, UK.; Edison P; Neurology Imaging Unit, Department of Medicine, Imperial College London, London, UK.
- Source
- Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE
- Subject
- Language
- English
Background: Amyloid plaque and tau-containing neurofibrillary tangles are important features of Alzheimer's disease (AD). However, the relationship between these processes is still debated.
Objective: We aimed to investigate local and distant relationships between tau and amyloid deposition in the cortex in mild cognitive impairment (MCI) and AD using PET imaging.
Methods: Seventy-nine subjects (51 controls, 13 amyloid-positive MCI subjects, and 15 amyloid positive AD subjects) underwent MRI and 18F-flutemetamol PET. All MCI/AD subjects and 8 healthy controls as well as 33 healthy control subjects from the ADNI dataset also had 18F-AV1451 PET. Regional and distant correlations were examined after sampling target-to-cerebellar ratio images. Biological parametric mapping was used to evaluate voxel level correlations locally.
Results: We found multiple clusters of voxels with highly significant positive correlations throughout the association cortex in both MCI and AD subjects.
Conclusion: The multiple clusters of positive correlations indicate that tau and amyloid may interact locally and be involved in disease progression. Our findings suggest that targeting both pathologies may be required.