Hyperpolarization of 15 N in an amino acid derivative.
- Resource Type
- Academic Journal
- Authors
- Saul P; Research Group for NMR Signal Enhancement, Max Planck Institute for Biophysical Chemistry Am Fassberg 11 37 077 Göttingen Germany stefan.gloeggler@mpibpc.mpg.de +49 551 3961 108.; Center for Biostructural Imaging of Neurodegeneration Von-Siebold-Straßze 3A 37 075 Göttingen Germany.; Mamone S; Research Group for NMR Signal Enhancement, Max Planck Institute for Biophysical Chemistry Am Fassberg 11 37 077 Göttingen Germany stefan.gloeggler@mpibpc.mpg.de +49 551 3961 108.; Center for Biostructural Imaging of Neurodegeneration Von-Siebold-Straßze 3A 37 075 Göttingen Germany.; Glöggler S; Research Group for NMR Signal Enhancement, Max Planck Institute for Biophysical Chemistry Am Fassberg 11 37 077 Göttingen Germany stefan.gloeggler@mpibpc.mpg.de +49 551 3961 108.; Center for Biostructural Imaging of Neurodegeneration Von-Siebold-Straßze 3A 37 075 Göttingen Germany.
- Source
- Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv Subsets: PubMed not MEDLINE
- Subject
- Language
- English
Hyperpolarization is a nuclear magnetic resonance (NMR) technique which can be used to significantly enhance the signal in NMR experiments. In recent years, the possibility to enhance the NMR signal of heteronuclei by the use of para -hydrogen induced polarization (PHIP) has gained attention, especially in the area of possible applications in magnetic resonance imaging (MRI). Herein we introduce a way to synthesize a fully deuterated, 15 N labelled amino acid derivative and the possibility to polarize the 15 N by means of hydrogenation with para -hydrogen to a polarization level of 0.18%. The longevity of the polarization with a longitudinal relaxation time of more than a minute can allow for the observation of dynamic processes and metabolic imaging in vivo . In addition, we observe the phenomenon of proton-deuterium exchange with a homogeneous catalyst leading to signal enhanced allyl moeities in the precursor.
Competing Interests: There are no conflicts to declare.
(This journal is © The Royal Society of Chemistry.)