Hepatitis B Virus Prevalence among HIV-Uninfected People Living in Rural and Peri-Urban Areas in Botswana.
- Resource Type
- Academic Journal
- Authors
- Anderson M; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; Africa Health Research Institute, Durban 4013, South Africa.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Mangogola T; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; Pan-African University (Life and Earth Sciences Institute), University of Ibadan, Ibadan 200132, Nigeria.; Phinius BB; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Private Bag UB 0022, Gaborone, Botswana.; Mpebe G; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; Department of Biological Sciences, Faculty of Science, University of Botswana, Private Bag UB 0022, Gaborone, Botswana.; Aimakhu CO; Pan-African University (Life and Earth Sciences Institute), University of Ibadan, Ibadan 200132, Nigeria.; Choga WT; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Private Bag UB 0022, Gaborone, Botswana.; Phakedi B; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; Bhebhe LN; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; Ditshwanelo D; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; Baruti K; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; Department of Biological Sciences, Faculty of Science, University of Botswana, Private Bag UB 0022, Gaborone, Botswana.; Mpofu-Dobo L; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; Department of Biological Sciences and Biotechnology, Faculty of Sciences, Botswana International University of Science and Technology, Private Bag 16, Palapye, Botswana.; Othusitse L; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; Ratsoma T; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; Department of Biological Sciences, Faculty of Science, University of Botswana, Private Bag UB 0022, Gaborone, Botswana.; Gaolathe T; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; Faculty of Medicine, University of Botswana, Private Bag UB 0022, Gaborone, Botswana.; Makhema J; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.; Shapiro R; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.; Lockman S; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.; Moyo S; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.; Division of Medical Virology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Stellenbosch, Private Bag X1, Matieland 7602, South Africa.; School of Health Systems and Public Health, University of Pretoria, Private Bag X20, Pretoria 0028, South Africa.; Gaseitsiwe S; Botswana Harvard Health Partnership, Private Bag BO320, Gaborone, Botswana.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
- Source
- Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101625893 Publication Model: Electronic Cited Medium: Print ISSN: 2076-2607 (Print) Linking ISSN: 20762607 NLM ISO Abbreviation: Microorganisms Subsets: PubMed not MEDLINE
- Subject
- Language
- English
- ISSN
- 2076-2607
(1) Background: we determined the prevalence of the hepatitis B virus (HBV) amongst people without human immunodeficiency virus (HIV) in rural and peri-urban areas in Botswana. (2) Methods: We screened for the hepatitis B surface antigen (HBsAg) from archived plasma samples of people without HIV (n = 2135) randomly selected from the Botswana Combination Prevention Program (BCPP) (2013-2018). We sequenced 415 bp of the surface region using BigDye sequencing chemistry. (3) Results: The median age of participants was 31 (IQR: 24-46) and 64% (1360/2135) were female. HBV prevalence was 4.0% (86/2135) [95% CI: 3.3-4.9]) and ranged between 0-9.2%. Older participants (>35 years) had increased odds of HBV positivity (OR: 1.94; 95% CI: [1.32-2.86]; p = 0.001). Thirteen samples were sequenced and seven (53.8%) were genotype A, three (23.1%) were genotype D and genotype E each. Clinically significant mutations were identified in the surface region, but no classic drug resistance mutations were identified. (4) Conclusions: We report an HBV prevalence of 4.0% (95% CI 3.3-4.9) among people without HIV in rural and peri-urban communities in Botswana with varying rates in different communities. A comprehensive national HBV program is required in Botswana to guide HBV prevention, testing and management.