Cep55: abscission boss or assistant?
- Resource Type
- Academic Journal
- Authors
- Little JN; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.; Dwyer ND; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA. Electronic address: ndwyer@virginia.edu.
- Source
- Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 9200566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3088 (Electronic) Linking ISSN: 09628924 NLM ISO Abbreviation: Trends Cell Biol Subsets: MEDLINE
- Subject
- Language
- English
Abscission is the second stage of cytokinesis. Cep55, a coiled-coil protein, is thought to recruit endosomal sorting complexes required for transport (ESCRTs) to the midbody to complete abscission. However, recent studies of Cep55-knockout mice reveal that most cells can complete abscission without Cep55. More work is needed to understand abscission mechanisms in different cell types.
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