Paediatric HIV infection: the potential for cure.
- Resource Type
- Academic Journal
- Authors
- Goulder PJ; Department of Paediatrics, University of Oxford, Oxford OX1 3SY, UK.; Lewin SR; The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne 3000, Australia.; Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne 3004, Australia.; Leitman EM; Department of Paediatrics, University of Oxford, Oxford OX1 3SY, UK.
- Source
- Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-1741 (Electronic) Linking ISSN: 14741733 NLM ISO Abbreviation: Nat Rev Immunol Subsets: MEDLINE
- Subject
- Language
- English
Recent anecdotal reports of HIV-infected children who received early antiretroviral therapy (ART) and showed sustained control of viral replication even after ART discontinuation have raised the question of whether there is greater intrinsic potential for HIV remission, or even eradication ('cure'), in paediatric infection than in adult infection. This Review describes the influence of early initiation of ART, of immune ontogeny and of maternal factors on the potential for HIV cure in children and discusses the unique immunotherapeutic opportunities and obstacles that paediatric infection may present.