Interocular Symmetry in Retinal Nerve Fiber Layer Thickness in Children: The Hong Kong Children Eye Study.
- Resource Type
- Academic Journal
- Authors
- Zhang XJ; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China.; Tianjin Eye Hospital, Tianjin, China.; Wang YM; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China.; Department of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany.; Jue Z; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China.; Chan HN; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China.; Lau YH; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China.; Zhang W; Tianjin Eye Hospital, Tianjin, China.; Kam KW; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China.; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, SAR, China.; Ip P; Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China.; Young AL; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China.; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, SAR, China.; Tham CC; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China.; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, SAR, China.; 4/F Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong.; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, SAR, China.; Pang CP; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China.; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, SAR, China.; Chen LJ; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China.; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, SAR, China.; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, SAR, China.; Yam JC; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China. yamcheuksing@cuhk.edu.hk.; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, SAR, China. yamcheuksing@cuhk.edu.hk.; 4/F Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong. yamcheuksing@cuhk.edu.hk.; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, SAR, China. yamcheuksing@cuhk.edu.hk.; Department of Ophthalmology, Hong Kong Children's Hospital, Hong Kong, SAR, China. yamcheuksing@cuhk.edu.hk.
- Source
- Publisher: Springer Healthcare Country of Publication: England NLM ID: 101634502 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2193-8245 (Print) NLM ISO Abbreviation: Ophthalmol Ther Subsets: PubMed not MEDLINE
- Subject
- Language
- English
- ISSN
- 2193-8245
Introduction: The aim of this work is to determine the interocular differences in peripapillary retinal nerve fiber layer (p-RNFL) thickness and its associations among school children in Hong Kong.
Methods: We conducted a population-based study including 4034 children aged 6-8 years from the Hong Kong Children Eye Study (HKCES). All participants received comprehensive ocular examinations where p-RNFL thickness was measured using spectral-domain optical coherence tomography (SD-OCT). The degree of symmetry between both eyes was analyzed and represented by intraclass correlation coefficient (ICC) values. Multivariable linear regression analysis was used to investigate the associations between ocular and systemic factors with p-RNFL thickness difference.
Results: The study included 4034 children with a mean age of 7.61 ± 0.98 years. The mean global p-RNFL thickness was 106.60 ± 9.41 μm in right eyes and 105.99 ± 9.30 μm in left eyes. The ICC for global p-RNFL difference was 0.866 (95% CI 0.858-0.873, p < 0.001). The symmetry displayed the largest values in nasal inferior quadrant with the ICC value of 0.736 (95% CI 0.721-0.749); and the smallest degree of symmetry was found to be in the superior temporal quadrant with the ICC value of 0.567 (95% CI 0.546-0.588). Axial length (AL) difference was found to have more pronounced correlation to interocular symmetry in p-RNFL thickness with the coefficient of 0.514 (p < 0.001).
Conclusions: Normal variation in interocular symmetry exists in children. Our results can contribute to the establishment of a standard reference for interocular differences in OCT parameters in children. The interocular differences in AL should be considered in the interpretation of RNFL symmetry, in terms of identifying children at risk of developing glaucoma or other ocular disorders.
(© 2023. The Author(s).)