Simultaneous differentiation of articular and transient cartilage: WNT-BMP interplay and its therapeutic implication.
- Resource Type
- Academic Journal
- Authors
- Biswas T; Indian Institute of Technology Kanpur, India.; Jaswal AP; Yadav US; Bandyopadhyay A
- Source
- Publisher: University of the Basque Country Press Country of Publication: Spain NLM ID: 8917470 Publication Model: Print Cited Medium: Internet ISSN: 1696-3547 (Electronic) Linking ISSN: 02146282 NLM ISO Abbreviation: Int J Dev Biol Subsets: MEDLINE
- Subject
- Language
- English
Limb skeleton forms through the process of endochondral ossification. This process of osteogenesis proceeds through an intermediate cartilage template and involves several stages of chondrocyte maturation and eventual bone formation. During the process of endochondral ossification, interplay between BMP and WNT signaling regulate simultaneous differentiation of articular and transient cartilage. In this review, we focus on the recent literature which explores the simultaneous differentiation of these two different types of cartilage. We discuss a new paradigm of developmental biology-inspired tissue engineering of bone and cartilage grafts and provide novel insight into treatment of osteoporosis.