Microvascular flow ultrasound imaging for retinoblastoma.
- Resource Type
- Academic Journal
- Authors
- Ramasubramanian A; Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address: aramasubramanian@mcw.edu.; Riemann M; Phoenix Children's Hospital, Phoenix, Arizona.; Brown A; University of Arizona College of Medicine, Phoenix, Arizona.; Abruzzo T; Phoenix Children's Hospital, Phoenix, Arizona; University of Arizona College of Medicine, Phoenix, Arizona; Mayo Clinic Alix School of Medicine, Scottsdale, Arizona; Creighton University, Phoenix, Arizona.; Goncalves LF; Phoenix Children's Hospital, Phoenix, Arizona; University of Arizona College of Medicine, Phoenix, Arizona; Mayo Clinic Alix School of Medicine, Scottsdale, Arizona; Creighton University, Phoenix, Arizona.
- Source
- Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9710011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-3933 (Electronic) Linking ISSN: 10918531 NLM ISO Abbreviation: J AAPOS Subsets: MEDLINE
- Subject
- Language
- English
Purpose: To present the results of a pilot study of microvascular flow imaging (MFI) in characterizing tumor vasculature of retinoblastoma.
Methods: The medical records of consecutive patients with retinoblastoma presenting at our institution between July 2019 and June 2022 that were imaged using MFI were reviewed retroactively. Each patient underwent diagnostic evaluation according to standard of care by examination under anesthesia with fluorescein angiography and ocular ultrasound imaging, including color Doppler and MFI.
Results: Thirteen eyes of 10 patients with retinoblastoma were included. MFI showed a prominent feeder vessel in 8 eyes, basket vasculature in 6 eyes and tumor bed vascularity in 10 eyes. MFI showed a more extensive vascular branching pattern that was not visible on color Doppler and fluorescein angiography in all eyes.
Conclusions: MFI of retinoblastoma patients could add information about tumor vascularity not detectable by color Doppler or fluorescein angiography. Further study is needed to determine whether this information could be used to predict prognosis for ocular salvage and tumor response to treatment.
(Copyright © 2024 American Association for Pediatric Ophthalmology and Strabismus. Published by Elsevier Inc. All rights reserved.)