Paget's Presentation of High-Grade Ductal Carcinoma In Situ (DCIS) in a Very Young Female With Breast Cancer 2 (BRCA2) Mutation.
- Resource Type
- Report
- Authors
- Butala S; Pediatrics, Rainbow Babies & Children's Hospital, Cleveland, USA.; Forestier C; Medicine, American University of the Caribbean School of Medicine, Cupecoy, SXM.; Obstetrics and Gynecology, Ascension Providence Hospital, Southfield, USA.; Nithiananthan S; Surgery, Ascension Providence Hospital, Southfield, USA.; Defran AJ; General Surgery, Ascension Providence Hospital, Southfield, USA.; Kuwajerwala NK; Breast Surgery, Ascension Providence Hospital, Southfield, USA.; Breast Surgery, Ascension Rochester Hills, Rochester Hills, USA.; Breast Surgery, Corewell Health, Troy, USA.
- Source
- Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
- Subject
- Language
- English
- ISSN
- 2168-8184
This is a case of a previously healthy 29-year-old female with erythema and skin excoriations of the left breast nipple-areolar complex (NAC). After a repeat trial and failure of topical hydrocortisone, a diagnostic mammogram and nipple biopsy revealed Paget's disease (PD) of the nipple with ductal carcinoma in situ (DCIS). A subsequent genetic analysis found a breast cancer 2 ( BRCA2 ) gene mutation. Treatment consisted of a left breast skin-sparing simple mastectomy with sentinel lymph node (SLN) biopsy and immediate tissue expander placement for implant reconstruction. Further management involved right breast short-interval surveillance with annual mammography and magnetic resonance imaging (MRI) with the possibility of prophylactic surgery along with oophorectomy after childbearing.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2024, Butala et al.)